Reaction: ABCC4 transports TPMP substrates from cytosol to extracellular region
- in pathway: Azathioprine ADME
ABCC4 is a multidrug resistance protein (MRP4) which can transport a wide range of organic anions but especially nucleotides and nucleotide analogues. When overexpressed, ABCC4 can lower the intracellular concentration of nucleoside/nucleotide analogues such as 6-mercaptopurine (6MP), after its conversion into its respective nucleotides (Wielinga et al. 2002, Ritter et al. 2005, Peng et al. 2008). This may lead to an impaired ability of 6MP to inhibit cell proliferation.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9750546
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-9750546