Reaction: SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol
- in pathway: Azathioprine ADME
Candidates for the transport of thiopurines like 6-mercaptopurine (6MP) into the cell include the sodium-dependent transporters SLC28A2 (concentrative Na(+)-nucleoside cotransporter 2, CNT2) and SLC28A3 (concentrative Na(+)-nucleoside cotransporter 3, CNT3). Down-regulation of these influx transporters may play a major role in 6MP resistance of cells (Fotoohi et al. 2006, Peng et al. 2008, Karim et al. 2011).
Reaction - small molecule participants:
Na+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-9751037
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Reaction input - small molecules:
sodium(1+)
Reaction output - small molecules:
sodium(1+)
Reactome.org link: R-HSA-9751037