Reaction: p-VAV1,2,3 exchange 6TGTP for GDP on RAC1
- in pathway: Azathioprine ADME
The guanine nucleotide exchange factors 1-3 (VAV1,2,3) act as guanine nucleotide exchange factors (GEFs) for Ras-related C3 botulinum toxin substrate (RAC1), catalysing the exchange of bound GDP for GTP (Heo et al. 2005, Jaiswal et al. 2013). To be fully active, VAV proteins are tyrosine-phosphorylated (Teramoto et al. 1997).
One of the active metabolites of azathioprine (6-thioguanosine triphosphate, 6TGTP) can block RAC1 activity by binding to it instead of GTP (presumably mediated by VAV proteins), thus converting a costimulatory signal into an apoptotic signal (Tiede et al. 2003).
One of the active metabolites of azathioprine (6-thioguanosine triphosphate, 6TGTP) can block RAC1 activity by binding to it instead of GTP (presumably mediated by VAV proteins), thus converting a costimulatory signal into an apoptotic signal (Tiede et al. 2003).
Reaction - small molecule participants:
GDP [cytosol]
6TGTP [cytosol]
Reactome.org reaction link: R-HSA-9751201
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Reaction input - small molecules:
6 thioguanosine triphosphate(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9751201