Reaction: HTR3 pentamers:5HT transport Na+,K+,Ca2+
The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015) Although heterpentamer composition can vary between the two receptors binding, the example 2xHTR3A:3xHTR3(B-E) is shown here. Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 complex opens the channel, which in turn, leads to an excitatory response in neurons and is permeable to sodium, potassium, and calcium ions (Miyake et al. 1995, Davies et al. 1999).
Reaction - small molecule participants:
K+ [cytosol]
Na+ [cytosol]
Ca2+ [cytosol]
K+ [extracellular region]
Ca2+ [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-975311
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Reaction input - small molecules:
potassium(1+)
calcium(2+)
sodium(1+)
Reaction output - small molecules:
potassium(1+)
sodium(1+)
calcium(2+)
Reactome.org link: R-HSA-975311