Reaction: ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3
- in pathway: Paracetamol ADME
Excretion of glucuronidated acetaminophen (APAP-GlcA) and sulfated acetaminophen (APAP-SO3) into bile involves the ATP-binding cassette sub-family C member 2 transporter (ABCC2) and the broad substrate specificity ATP-binding cassette transporter (ABCG2), both found in the canalicular membrane of hepatocytes where they secrete drug conjugates into bile (Giacomini et al. 2010, Kidron et al. 2012, review McGill & Jaeschke 2013).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9753278
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-9753278