Reaction: GSTs transfer GSH to NAPQI to form APAP-SG
- in pathway: Paracetamol ADME
N-acetyl-p-benzoquinone imine (NAPQI) can bind to the cysteine thiol of GSH, a critical mechanism of detoxification. The reaction of NAPQI with GSH can occur both spontaneously and enzymatically (Coles et al. 1998).
Reaction - small molecule participants:
H2O [cytosol]
APAP-SG [cytosol]
NAPQI [cytosol]
GSH [cytosol]
Reactome.org reaction link: R-HSA-9753280
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Reaction input - small molecules:
N-Acetyl-p-benzoquinonimine
glutathionate(1-)
Reaction output - small molecules:
water
acetaminophen glutathione conjugate
Reactome.org link: R-HSA-9753280