Reaction: ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3
- in pathway: Paracetamol ADME
Glucuronidated acetaminophen (APAP-GlcA) and sulfated acetaminophen (APAP-SO3) can also be secreted into blood via the ATP-binding cassette sub-family C member 3 and 4 transporters (ABCC3 and ABCC4), both found at the basolateral surface of hepatocytes (Giacomini et al. 2010, review McGill & Jaeschke 2013, Koenderink et al. 2020).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9753283
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-9753283