Reaction: ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region
- in pathway: Paracetamol ADME
The ATP-binding cassette sub-family C member transporters (ABCCs, aka multidrug resistance-associated proteins, MRPs) mediate the export of organic anions and drugs from cells. Induction of ABCC expression after APAP-induced liver failure may represent a compensatory mechanism of damaged hepatocytes to reduce accumulation of potentially toxic compounds. ABCC1, 4 and 5 are thought to efflux the cysteine- and mercapto-conjugates of paracetamol (APAP-Cys and APAP-Mer respectively) from hepatocytes (Barnes et al. 2007).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9753284
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-9753284