Reaction: CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly
- in pathway: Paracetamol ADME
Cytosolic, non-specific peptidase (CNDP2) can hydrolyse cysteinylglycine (CysGly) to release cysteine (L-Cys) and glycine (Gly) (Tuefel et al. 2003). CNDP2 is functional as a homodimer and is thought to require 2 Mn2+ ions per subunit.
Reaction - small molecule participants:
APAP-Cys [cytosol]
Gly [cytosol]
H2O [cytosol]
APAP-CysGly [cytosol]
Reactome.org reaction link: R-HSA-9753632
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Reaction input - small molecules:
water
Paracetamol-Cys-Gly conjugate
Reaction output - small molecules:
S-(5-acetamido-2-hydroxyphenyl)cysteine zwitterion
glycine zwitterion
Reactome.org link: R-HSA-9753632