Reaction: NAT1,2 acetylate APAP-Cys to APAP-Mer

- in pathway: Paracetamol ADME
Human arylamine N-acetyltransferases (NATs) are expressed as two polymorphic isoforms, NAT1 and NAT2, which have toxicologically significant functions in the detoxification of xenobiotic arylamines by N-acetylation (Liu et al. 2009, Klaassen 2013). NAT1 is located in virtually every tissue whereas NAT2 is mainly expressed in the liver and gut. Slow acetylators of polymorphic NAT2 may suffer more often from side-effects of NAT substrates than fast acetylators due to its inhibition by many drugs (Chien et al. 1997).
Reaction - small molecule participants:
APAP-Mer [cytosol]
CoA-SH [cytosol]
Ac-CoA [cytosol]
APAP-Cys [cytosol]
Reactome.org reaction link: R-HSA-9753676

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Reaction input - small molecules:
acetyl-CoA(4-)
ChEBI:57288
S-(5-acetamido-2-hydroxyphenyl)cysteine zwitterion
ChEBI:133067
Reaction output - small molecules:
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate
ChEBI:133438
coenzyme A(4-)
ChEBI:57287
Reactome.org link: R-HSA-9753676