Reaction: GLRA:GLRB:Gly transports extracellular Cl- to cytosol
The glycine receptor (GLR) is a ligand-gated ion channel. It is functional as a heteropentamer, consisting of alpha (GLRA) and beta (GLRB) subunits. With no ligand bound, the receptor complex is closed to chloride ions. Binding of the inhibitory neurotransmitter glycine (Gly) to this receptor complex increases chloride conductance into neurons and thus produces hyperpolarization (inhibition of neuronal firing) (Grenningloh et al. 1990, Nikolic et al. 1998, Handford et al. 1996).
Reaction - small molecule participants:
Cl- [cytosol]
Cl- [extracellular region]
Reactome.org reaction link: R-HSA-975389
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Reaction input - small molecules:
chloride
Reaction output - small molecules:
chloride
Reactome.org link: R-HSA-975389