Reaction: GABRR pentamers:GABA transports extracellular Cl- to cytosol
- in pathway: GABA receptor activation
GABA A (rho) receptors are highly expressed in the retina and are functional homopentamers of rho subunits. These receptors were formerly called GABA C receptors.
The GABA(A)-rho receptor (GABRR) is expressed in many areas of the brain, but in contrast to other GABA(A) receptors, has especially high expression in the retina. It is functional as a homopentamer and is permeable to chloride ions when GABA binds to it (Cutting et al. 1991, Cutting et al. 1992, Bailey et al. 1990).
Reaction - small molecule participants:
Cl- [cytosol]
Cl- [extracellular region]
Reactome.org reaction link: R-HSA-975449
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Reaction input - small molecules:
chloride
Reaction output - small molecules:
chloride
Reactome.org link: R-HSA-975449