Reaction: NT5C2 tetramer phosphorylates RBV
- in pathway: Ribavirin ADME
Ribavirin (RBV) phosphorylation to ribavirin monophosphate (RBV-MP) can be catalyzed by the 5′-nucleotidase NT5C2, with a catalytic efficiency much better than that by adenosine kinase (ADK) (Wu et al, 2005). This appears to be the rate-limiting step in the intracellular ribavirin metabolism resulting in the triphosphate (Page and Connor, 1990; Wallden and Nordlund, 2011).
Reaction - small molecule participants:
Ino [cytosol]
RBV-MP [cytosol]
IMP [cytosol]
Reactome.org reaction link: R-HSA-9754916
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Reaction input - small molecules:
IMP(2-)
Reaction output - small molecules:
inosine
ribavirin 5'-monophosphate(2-)
Reactome.org link: R-HSA-9754916