Reaction: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol
- in pathway: Ribavirin ADME
The concentrative sodium/nucleoside cotransporters 2 and 3 (CNT2, SLC28A2 and CNT3, SLC28C3) import ribavirin (RBV) together with sodium ions (Na+) into cells. As the transporters are expressed on the plasma membranes of many cell types, RBV may be absorbed extensively (Errasti-Murugarren et al, 2007; Podgorska et al, 2005). Kinetic studies in Xenopus laevis oocytes point to a possible interaction of SLC29A1 with the SLC28A3 transport process (Yamamoto et al, 2010). Presence of interferon-alpha (IFNA) enhances uptake by apparent promotion of SLC28A2 translocation to the plasma membrane (probably by upregulation of SLC28A2 expression), which explains synergistic effects in treatment with both drugs (Pinilla-Macua et al, 2014).
Reaction - small molecule participants:
Na+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-9754934
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Reaction input - small molecules:
sodium(1+)
Reaction output - small molecules:
sodium(1+)
Reactome.org link: R-HSA-9754934