Reaction: ADA deamidates RBV
- in pathway: Ribavirin ADME
Ribavirin (RBV) undergoes hydrolytic deamination to its carboxylic acid derivative (RBV-COOH, ICN3297), which does not possess any antiviral activity. The reaction is catalyzed by adenosine deaminase (ADA). As the amount of detectable RBV-COOH is low, deamination is not important in RBV catabolism (Miller et al, 1977; Wu et al, 2003).
Reaction - small molecule participants:
RBV-COOH [cytosol]
NH4+ [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9754964
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Reaction input - small molecules:
water
Reaction output - small molecules:
ribavirin carboxylate
ammonium
Reactome.org link: R-HSA-9754964