Reaction: ADK phosphorylates RBV
- in pathway: Ribavirin ADME
Adenosine kinase (ADK) takes part in phosphorylation of ribavirin (RBV) in erythrocytes (Page and Connor, 1990). While 5′-nucleotidase (NT5C2) has a catalytic efficiency much better than that of adenosine kinase (ADK), the actual contribution of ADK to RBV phosphorylation depends on the physiological concentrations of enzymes and other effectors, which are unknown (Wu et al, 2005). Phosphorylation to ribavirin monophosphate (RBV-MP) appears to be the rate-limiting step in the intracellular ribavirin metabolism resulting in the triphosphate (Page and Connor, 1990).
Reaction - small molecule participants:
ADP [cytosol]
RBV-MP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9754974
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ribavirin 5'-monophosphate(2-)
Reactome.org link: R-HSA-9754974