Reaction: Unknown kinase phosphorylates RBV-MP
- in pathway: Ribavirin ADME
Ribavirin diphosphate (RBV-DP) is the intermediate of ribavirin (RBV) activation by phosphorylation, and it is found in cells treated with RBV (Miller et al, 1977; Glue 1999). The enzyme responsible for phosphorylation of the monophosphate is not known. A possible candidate would be cytosolic guanylate kinase 1 (GUK1) which is known to activate carbovir, 6-mercaptopurine and other drugs (see e.g. Miller et al, 1977; Miller et al, 1992 about these activities).
Reaction - small molecule participants:
RBV-DP [cytosol]
ADP [cytosol]
ATP [cytosol]
RBV-MP [cytosol]
Reactome.org reaction link: R-HSA-9754978
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Reaction input - small molecules:
ATP(4-)
ribavirin 5'-monophosphate(2-)
Reaction output - small molecules:
ribavirin 5'-diphosphate(3-)
ADP(3-)
Reactome.org link: R-HSA-9754978