Reaction: ITPA dimer dephosphorylates RBV-TP to RBV-MP
- in pathway: Ribavirin ADME
Ribavirin triphosphate (RBV-TP) was dephosphorylated in vitro by recombinant ITP triphosphatase (ITPAse, ITPA) to a similar extent as its naturally occurring substrate ITP. Reduced ITPase activity in one third of humans causes increased intracellular levels of RBV-TP, leading to increased treatment efficacy (Nystrom et al, 2018; Tanaka et al, 2018). Polymorphisms in the gene encoding ITPase (ITPA) have been associated with protection against ribavirin-induced anemia (Fellay et al, 2010).
Reaction - small molecule participants:
PPi [cytosol]
RBV-MP [cytosol]
H2O [cytosol]
RBV-TP [cytosol]
Reactome.org reaction link: R-HSA-9755030
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Reaction input - small molecules:
water
ribavirin 5'-triphosphate(4-)
Reaction output - small molecules:
diphosphate(3-)
ribavirin 5'-monophosphate(2-)
Reactome.org link: R-HSA-9755030