Reaction: NT5C2 tetramer dephosphorylates RBV-MP
- in pathway: Ribavirin ADME
Nucleate cell types can hydrolyze ribavirin monophosphate (RBV-MP) to ribavirin (RBV). The enzymes possibly responsible for the reaction are cytosolic purine 5'-nucleotidase (NT5C2) and alkaline phosphatases (Page and Connor, 1990).
Reaction - small molecule participants:
phosphate [cytosol]
H2O [cytosol]
RBV-MP [cytosol]
Reactome.org reaction link: R-HSA-9755078
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Reaction input - small molecules:
water
ribavirin 5'-monophosphate(2-)
Reaction output - small molecules:
phosphate(3-)
Reactome.org link: R-HSA-9755078