Reaction: PNLIP:CLPS hydrolyses RPALM to atROL and PALM
- in pathway: Digestion of dietary lipid
Part of nutritional vitamin A is in the form of retinyl esters (REs). The main fatty acids which can form esters with retinol are palmitate, oleate, stearate and linoleate. REs are digested together with other lipids, and by the same enzymes. Pancreatic lipase catalyses the hydrolysis of RE to all-trans-retinol (atROL) and fatty acid which are then both taken up by enterocytic cell membranes (Bennekum et al. 2000).
Reaction - small molecule participants:
atROL [plasma membrane]
PALM [plasma membrane]
H2O [extracellular region]
RPALM [extracellular region]
atROL [plasma membrane]
PALM [plasma membrane]
H2O [extracellular region]
RPALM [extracellular region]
Reactome.org reaction link: R-HSA-975593
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Reaction input - small molecules:
water
all-trans-retinyl palmitate
water
all-trans-retinyl palmitate
Reaction output - small molecules:
all-trans-retinol
hexadecanoic acid
all-trans-retinol
hexadecanoic acid
Reactome.org link: R-HSA-975593