Reaction: PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV
- in pathway: Atorvastatin ADME
Serum paraoxonase/arylesterase 1 and Serum paraoxonase/lactonase 3 (PON1 and PON3 respectively) were identified as the major enzymes involved in the hydrolysis of atorvastatin-lactone (ATVL) to atorvastatin (ATV) in human liver (Riedmaier et al. 2011). They are predominantly associated with the ER membrane (Gonzalvo et al. 1998, Riedmaier et al. 2011). It is very likely that these two enzymes also convert the corresponding 2-hydroxyl-metabolite.
Reaction - small molecule participants:
H+ [cytosol]
2-OH-ATVL [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9756136
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Reaction input - small molecules:
2-hydroxyatorvastatin lactone
water
Reaction output - small molecules:
hydron
Reactome.org link: R-HSA-9756136