Reaction: Hydroxyl radicals oxidize ST to 2,3-DHBA
- in pathway: Aspirin ADME
2,3-Dihydroxybenzoate (2,3-DHBA) can be formed by hydroxyl radicals attacking salicylate (ST) in animal cells (Ingelman-Sundberg et al, 1991). This result could not be confirmed in human liver microsomes using a different setup (Bojic et al, 2015)
Reaction - small molecule participants:
2,3-DHBA [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
hydroxyl [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9757462
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Reaction input - small molecules:
salicylate
hydroxyl
Reaction output - small molecules:
2,3-dihydroxybenzoate
Reactome.org link: R-HSA-9757462