Reaction: Trimming of mannoses on the alpha1,6 arm by MAN2A1
The removal of mannoses on the alpha,1,6 arm by MAN2A1 or MAN2A2 is required for efficient formation of complex-type N-glycans (Misago M et al, 1995; Crispin M et al, 2007). These two enzymes carry out the same function and the disruption of both inhibits the formation of complex N-glycans in vivo (Akama TO et al, 2006).
Reaction - small molecule participants:
Man [Golgi lumen]
(GlcNAc)3 (Man)3 (Asn)1 [Golgi lumen]
(GlcNAc)3 (Man)5 (Asn)1 [Golgi lumen]
Reactome.org reaction link: R-HSA-975814
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Reaction input - small molecules:
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-Asn residue
Reaction output - small molecules:
D-mannopyranose
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-Asn residue
Reactome.org link: R-HSA-975814