Reaction: UGT2B7,2B17,1A3 glucuronidates PRED metabolites
- in pathway: Prednisone ADME
UDP-glucuronosyltransferase 2B7 (UGT2B7) was found in vitro to be the main enzyme glucuronidating prednisone (PREDN) with UGT2B17 and UGT1A3 having weak activity (Innocenti et al, 2005). It is probable that these glucuronosyltransferases are responsible for glucuronidation of other PREDN metabolites that show up in urinary output (Matabosch et al, 2015; Mazzarino et al, 2019).
Reaction - small molecule participants:
H+ [cytosol]
UDP [cytosol]
UDP-GlcA [cytosol]
Reactome.org reaction link: R-HSA-9758661
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
hydron
UDP(3-)
Reactome.org link: R-HSA-9758661