Reaction: CYP3A4 oxidizes PREDN,PREDL
- in pathway: Prednisone ADME
Prednisolone (PREDL) strongly induces the expression of cytochrome P450 3A4 (CYP3A4) in hepatic cells (Sumida et al, 2000; Usui et al, 2002). Co-application of the CYP3A4 inhibitor ketoconazole with predisolone decreased urinary output of the metabolite 6beta-hydroxyprednisolone (6βOH-PREDL) significantly (Zürcher et al, 1989). As CYP3A4 also hydroxylates cortisol to the 6betaOH-product (Peng et al, 2011) it is probable that CYP3A4 oxidizes PREDN to 6βOH-PREDN, and PREDL to 6βOH-PREDL.
Reaction - small molecule participants:
H2O [cytosol]
H+ [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9758674
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Reaction input - small molecules:
dioxygen
Reaction output - small molecules:
water
hydron
Reactome.org link: R-HSA-9758674