Reaction: Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV
- in pathway: N-Glycan antennae elongation
N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addition of GlcNAc beta,1,4 on the GlcNAc beta1,2 Man,alpha1,3 arm of both complex and hybrid N-glycans (Oguri S et al, 2006). Two human GnT-IV isozymes have been characterized (MGAT4A, MGAT4B) , plus a putative MGAT4C on chromosome 2 (Furukawa T et al, 1999). Aberrant expression of MGAT4A or MGAT4B is associated with pancreatic cancer (Ide Y et al, 2006; Kudo T et al , 2007)
Reaction - small molecule participants:
UDP-GlcNAc [Golgi lumen]
NGP [Golgi lumen]
Reactome.org reaction link: R-HSA-975903
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Reaction input - small molecules:
UDP-N-acetyl-alpha-D-glucosamine(2-)
N-glycan
Reaction output - small molecules:
Reactome.org link: R-HSA-975903