Reaction: Addition of GlcNAc to position 5 by MGAT5
- in pathway: N-Glycan antennae elongation
N-acetylglucosaminyltransferase (GnT)-V catalyzes the addition of GlcNAc beta 1,4 on the GlcNAc beta1,2 Man,alpha1,6 arm of complex type N-Glycans (Park C et al, 1999; Granowski M et al, 2000; Wang L et al, 2007). The activity of MGAT5 competes with MGAT3 (Pinho SS et al, 2009) and is associated with gastric cancer (Tian H et al, 2008) and multiple sclerosis (Brynedal B et al, 2010).
Reaction - small molecule participants:
UDP-GlcNAc [Golgi lumen]
NGP [Golgi lumen]
Reactome.org reaction link: R-HSA-975916
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Reaction input - small molecules:
UDP-N-acetyl-alpha-D-glucosamine(2-)
N-glycan
Reaction output - small molecules:
Reactome.org link: R-HSA-975916