Reaction: Addition of galactose by beta 4-galactosyltransferases
- in pathway: N-Glycan antennae elongation
Addition of a galactose residue on N-acetylglucosamine. The family of beta 4-galactosyltransferases is composed by at least six known members with different K(m) and acceptor specifities (Guo S et al, 2001) and probably originated by duplication (Lo NW et al, 1998). B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (Hansske B et al, 2002), and is expressed as two splicing isoforms of which only one is localizated in the Golgi system (Lopez LC et al, 1991; Schaub BE et al, 2006). B4GALT2 is key in the regulation of proteins involved in neuronal development (Sasaki N et
al, 2005).
al, 2005).
Reaction - small molecule participants:
UDP-Gal [Golgi lumen]
NGP [Golgi lumen]
Reactome.org reaction link: R-HSA-975919
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Reaction input - small molecules:
UDP-alpha-D-galactose(2-)
N-glycan
Reaction output - small molecules:
Reactome.org link: R-HSA-975919