Reaction: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
- in pathway: Cobalamin (Cbl) metabolism
Cob(I)alamin bound to MMACHC (Methylmalonic aciduria and homocystinuria type C protein, aka cblC protein) is oxidized to cob(II)alamin. Possible mechanisms for this conversion have been described (Banerjee et al. 2021). The reaction is annotated here without an enzyme catalyst; its chemistry is inferred from that of the bacterial system described by Walker et al. (1969).
Reaction - small molecule participants:
NADH [cytosol]
H+ [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-9759549
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Reaction input - small molecules:
hydron
NAD(1-)
Reaction output - small molecules:
NADH(2-)
Reactome.org link: R-HSA-9759549