Reaction: SQSTM1 oligomer is phosphorylated
- in pathway: KEAP1-NFE2L2 pathway
SQSTM1 is phosphorylated at serine 349 by an unknown kinase (Ichimura et al, 2013; reviewed in Jiang et al, 2015; Lamark et al, 2017; Baird and Yamamoto, 2020). This serine residues lies in the STGE motif of SQSTM1 that mediates the interaction with the KELCH1 domain of KEAP1, and phosphorylation increases the strength of the binding. Binding of phosphorylated SQSTM1 to KEAP1 competes with NFE2L2 for the site and consequently stabilizes NFE2L2 (Ichimura et al, 2013; reviewed in Jiang et al, 2015; Lamark et al, 2017; Baird and Yamamoto, 2020).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9766532
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9766532