Reaction: ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
- in pathway: Termination of O-glycan biosynthesis
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as Tn antigens (Stamenkovic et al. 1990, Marcos et al. 2004). The resultant sialyl Tn antigens are highly expressed in several human carcinomas and are associated with carcinoma aggressiveness and poor prognosis (Sewell et al. 2006, Lakshmanan et al. 2021).
Reaction - small molecule participants:
CMP [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Reactome.org reaction link: R-HSA-977071
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-977071