Reaction: Histidine is decarboxylated to histamine
- in pathway: Histidine catabolism
Decarboxylation of L-Histidine happens analogously to other decarboxylations of amino acids. It uses the cofactor pyridoxal phosphate and is catalyzed by histidine decarboxylase (Mamune-Sato et al, 1992).
Reaction - small molecule participants:
Hist [cytosol]
CO2 [cytosol]
L-His [cytosol]
Reactome.org reaction link: R-HSA-977301
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Reaction input - small molecules:
L-histidinium(1+)
Reaction output - small molecules:
histaminium
carbon dioxide
Reactome.org link: R-HSA-977301