Reaction: PHGDH tetramer dehydrogenates 3PG
- in pathway: Serine biosynthesis
Serine biosynthesis starts from 3-phosphoglycerate (3PG), a glycolysis intermediate. Its dehydrogenation to 3-phosphonooxypyruvic acid (3POPA) is catalysed by tetrameric phosphoglycerate dehydrogenase (PHGDH). (Tabatabaie et al. 2009).
Reaction - small molecule participants:
3POPA [cytosol]
H+ [cytosol]
NADH [cytosol]
NAD+ [cytosol]
3PG [cytosol]
Reactome.org reaction link: R-HSA-977348
======
Reaction input - small molecules:
NAD(1-)
3-phosphonato-D-glycerate(3-)
Reaction output - small molecules:
3-phosphonooxypyruvic acid
hydron
NADH(2-)
Reactome.org link: R-HSA-977348