Reaction: SLC35D2 exchanges UDP-D-glucose for UMP
- in pathway: Transport of nucleotide sugars
The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars including UDP-D-glucose into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).
Reaction - small molecule participants:
UMP [cytosol]
UDP-D-glucose(2-) [Golgi lumen]
UMP [Golgi lumen]
UDP-D-glucose(2-) [cytosol]
Reactome.org reaction link: R-HSA-9792608
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Reaction input - small molecules:
uridine 5'-monophosphate(2-)
UDP-D-glucose(2-)
Reaction output - small molecules:
uridine 5'-monophosphate(2-)
UDP-D-glucose(2-)
Reactome.org link: R-HSA-9792608