Reaction: ABCG2 transports Cipro from intestinal cell to extracellular space
- in pathway: Ciprofloxacin ADME
Inhibition studies with Caco-2 cells show there may be a number of transport proteins involved in the transport of ciprofloxacin (Cipro) through GI cells (Cavet et al, 1997). Secretion of Cipro into the GI lumen involves two distinct transport steps: at the basolateral cell membrane, Cipro is accumulated within the cytosol, with secretion then occurring across the apical membrane (Lowes & Simmons, 2002; Xia et al, 2005; Haslam et al, 2011; reviewed by Alvarez et al, 2008). The importance of this process relative to the main excretion pathways (renal and biliary) is unclear, however.
Reaction - small molecule participants:
ADP [cytosol]
PI [cytosol]
Cipro [extracellular region]
H2O [cytosol]
Cipro [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9794120
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Reaction input - small molecules:
water
ciprofloxacin zwitterion
ATP(4-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol(1-)
ciprofloxacin zwitterion
Reactome.org link: R-HSA-9794120