Reaction: Basolateral transport of Cipro into intestinal cell
- in pathway: Ciprofloxacin ADME
Non-renal clearance of ciprofloxacin is mainly due to active transintestinal secretion as well as liver metabolism (Bayer, 2021). When serum concentrations are high, Cipro zwitterion is transported by an unknown protein from serum through the basolateral membrane into gut epithelial cells. Membrane transporters of the major facilitator type act in response to chemiosmotic gradients. The facilitator SLCO2B1 (OATP2B1) is localized in basolateral membranes of jejunum epithelial cells and is a possible candidate for catalyzing the influx of Cipro from serum extracellular space (Keiser et al, 2017; Chen et al, 2020).
Reaction - small molecule participants:
Cipro [cytosol]
Cipro [extracellular region]
Reactome.org reaction link: R-HSA-9794352
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Reaction input - small molecules:
ciprofloxacin zwitterion
Reaction output - small molecules:
ciprofloxacin zwitterion
Reactome.org link: R-HSA-9794352