Reaction: ALB binds Cipro
- in pathway: Ciprofloxacin ADME
Distribution and free concentration of various drugs can be significantly altered as a result of their binding to serum albumin (ALB). About 20 per cent of plasma ciprofloxacin (Cipro) is bound to protein (Joos et al, 1985; reviewed by Wolfson & Hooper, 1991). Cipro binds to ALB in a pH dependent manner. Slight pH variations in different extracellular environments may affect Cipro-ALB interaction (Ahmad et al, 2006; Anand et al, 2012; Varshney et al, 2014). As shown in experiments with bovine albumin, ALB undergoes significant changes in its secondary structure during the interaction (Paul et al, 2017; Ipte et al, 2019).
Reaction - small molecule participants:
Cipro [extracellular region]
Reactome.org reaction link: R-HSA-9794444
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Reaction input - small molecules:
ciprofloxacin zwitterion
Reaction output - small molecules:
Reactome.org link: R-HSA-9794444