Reaction: SLC22A1 transports Cipro into renal cell
- in pathway: Ciprofloxacin ADME
Because of its high renal clearance, ciprofloxacin (Cipro) is probably not reabsorbed by renal tubular cells. In addition to glomerular secretion, Cipro is also secreted contraluminally by tubular cells (reviewed by Sörgel & Kinzig, 1993). The first step of contraluminal tubular secretion consists of facilitated transport of Cipro by SLC22A1 (OCT1) through the basolateral parts of the membrane (Mulgaonkar et al, 2013). In rat, facilitated basolateral transport by Slc47a1 (rMATE1) has been shown (Ohta et al, 2009).
Reaction - small molecule participants:
Cipro [cytosol]
Cipro [extracellular region]
Reactome.org reaction link: R-HSA-9794523
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Reaction input - small molecules:
ciprofloxacin zwitterion
Reaction output - small molecules:
ciprofloxacin zwitterion
Reactome.org link: R-HSA-9794523