Reaction: ABCG2 transports Cipro from hepatic cell to extracellular space
- in pathway: Ciprofloxacin ADME
Concentration of ciprofloxacin (Cipro) in bile is greater than in hepatic cells. ABCG2 is localized in the apical membrane of hepatic cells (Matsushima et al, 2005). ABCG2 transports Cipro to extracellular space which, in this reaction, is the bile duct lumen (Ando et al, 2007; reviewed by Alvarez et al, 2008).
Reaction - small molecule participants:
ADP [cytosol]
PI [cytosol]
Cipro [extracellular region]
H2O [cytosol]
Cipro [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9794572
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Reaction input - small molecules:
water
ciprofloxacin zwitterion
ATP(4-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol(1-)
ciprofloxacin zwitterion
Reactome.org link: R-HSA-9794572