Reaction: Cipro is sulfonated to sulfo-Cipro
- in pathway: Ciprofloxacin ADME
Sulfociprofloxacin (sulfo-Cipro) appears as major metabolite of ciprofloxacin (Cipro) in faeces. The responsible enzymes are probably hepatic sulfotransferases (SULT) which act on the intermediate N4-hydroxyciprofloxacin, which itself is a probable biotransformation product of Cipro, catalyzed by a hepatic cytochrome P450 (reviewed by Bolledulla et al, 2014 and Sörgel, 1989; human sulfotransferases are reviewed in Gamage et al, 2006).
Reaction - small molecule participants:
sulfo-Cipro [cytosol]
PAP [cytosol]
Cipro [cytosol]
O2 [cytosol]
PAPS [cytosol]
Reactome.org reaction link: R-HSA-9795134
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Reaction input - small molecules:
ciprofloxacin zwitterion
dioxygen
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
sulfociprofloxacin
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-9795134