Reaction: Basolateral excretion of oxo-Cipro
- in pathway: Ciprofloxacin ADME
Oxociprofloxacin (oxo-Cipro), as the major ciprofloxacin metabolite in urine, is transported by an unknown active transporter from the cytosol of primary hepatocytes back to extracellular space of the blood vessels (reviewed by Sörgel, 1989). There are two active transporters highly expressed in the basolateral membranes of hepatocytes: ATP-binding cassette sub-family C members 3 and 4 (ABCC3, ABCC4) (reviewed by Jetter & Kullack-Ublick, 2019). It is possible that ABCC3 and/or ABCC4 are responsible for excretion of oxo-Cipro into blood plasma.
Reaction - small molecule participants:
oxo-Cipro [extracellular region]
oxo-Cipro [cytosol]
Reactome.org reaction link: R-HSA-9795153
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Reaction input - small molecules:
3-oxociprofloxacin
Reaction output - small molecules:
3-oxociprofloxacin
Reactome.org link: R-HSA-9795153