Reaction: SLC22A1 transports Cipro into hepatic cell
- in pathway: Ciprofloxacin ADME
Facilitated transport of Cipro through the basolateral parts of the hepatocyte membrane is the most probable mechanism by which Cipro enters hepatic cells (reviewed by Jetter & Kullak-Ublick, 2019). Transport of drugs by solute carrier family 22 member 1 (SLC22A1, OCT1), highly expressed in liver, is inhibited by most fluoroquinolones including Cipro (Mulgaonkar et al, 2013). Direct binding of Cipro to SLC22A1 or its role as substrate has not been shown, however.
Reaction - small molecule participants:
Cipro [cytosol]
Cipro [extracellular region]
Reactome.org reaction link: R-HSA-9795207
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Reaction input - small molecules:
ciprofloxacin zwitterion
Reaction output - small molecules:
ciprofloxacin zwitterion
Reactome.org link: R-HSA-9795207