Reaction: ERO1B oxidizes P4HB
- in pathway: Insulin processing
ERO1B catalyzes the reduction of the disulfide bond in HC53,56-P4HB to form P4HB plus H2O2 (Gross et al. 2006; Mezghrani et al. 2001; Wang et al. 2011). Studies of knockout mutant mice are consistent with this role for ERO1B, while also suggesting that other oxidoreductases, not annotated here, could play a role in this process in vivo (Zito et al. 2010a b). See also the review of oxidative protein folding by Hudson et al. (2015).
Reaction - small molecule participants:
H2O2 [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9817575
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Reaction input - small molecules:
dioxygen
Reaction output - small molecules:
hydrogen peroxide
Reactome.org link: R-HSA-9817575