Reaction: ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen
- in pathway: Termination of O-glycan biosynthesis
The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.
Reaction - small molecule participants:
CMP [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Reactome.org reaction link: R-HSA-981809
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-981809