Reaction: AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote
Before and during zygotic genome activation, AGO2 bound to an endogenous small interfering RNA (endosiRNA) derived from transcripts of a maternally expressed gene (AGO2:endosiRNA) hydrolyzes the cognate maternal mRNA at the site of complementarity with the endosiRNA (inferred from mouse homologs). In mouse early embryos, Ago2 is involved in the decay of over half of the maternal mRNAs (Zhang et al. 2020).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9820842
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9820842