Reaction: CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP
BTG4 bound to PABPN1L and eIF4E of the mRNP recruits the CCR4-NOT complex via an interaction between BTG4 and CNOT7 of the CCR4-NOT complex (inferred from mouse homologs). CNOT7 then deadenylates the mRNA, targeting the mRNA for degradation (inferred from mouse homologs).
Reaction - small molecule participants:
AMP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9822311
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Reaction input - small molecules:
water
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-9822311