Reaction: CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA
ZFP36L2 bound to AU-rich elements of specific mRNAs recruits the CCR4-NOT complex via an interaction between ZFP36L2 and CNOT6L of the CCR4-NOT complex (inferred from mouse homologs). CNOT6L then deadenylates the mRNA, targeting the mRNA for degradation (inferred from mouse homologs).
Reaction - small molecule participants:
AMP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9822335
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Reaction input - small molecules:
water
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-9822335