Reaction: Transport of Antigen peptide in to ER
Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
oligopeptide fragment [endoplasmic reticulum lumen]
H2O [cytosol]
ATP [cytosol]
oligopeptide fragment (8-16aa) [cytosol]
Reactome.org reaction link: R-HSA-983144
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Reaction input - small molecules:
water
ATP(4-)
oligopeptide
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
oligopeptide
Reactome.org link: R-HSA-983144