Reaction: Trimming of peptides in ER
Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
Reaction - small molecule participants:
L-amino acid [endoplasmic reticulum lumen]
Antigen peptide [endoplasmic reticulum lumen]
oligopeptide fragment [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-983158
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Reaction input - small molecules:
oligopeptide
Reaction output - small molecules:
L-alpha-amino acid zwitterion
oligopeptide
Reactome.org link: R-HSA-983158