Reaction: Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
Reaction - small molecule participants:
oligopeptide fragment (8-16aa) [cytosol]
L-amino acid [cytosol]
precursor peptide fragment (>16 aa) [cytosol]
Reactome.org reaction link: R-HSA-983162
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Reaction input - small molecules:
oligopeptide
Reaction output - small molecules:
oligopeptide
L-alpha-amino acid zwitterion
Reactome.org link: R-HSA-983162